Crystallization in a sphere — ScienceDaily

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Crystallization is the assembly of atoms or molecules into highly ordered solid crystals, which occurs in natural, biological, and artificial systems. However, crystallization in confined spaces, such as the formation of the protein shell of a virus, is poorly understood. Researchers are trying to control the structure of the final crystal formed in a confined space to obtain crystals with desired properties, which requires thorough knowledge of the crystallization process.

A research group at Institute of Industrial Science, The University of Tokyo and Fudan University led by Hajime Tanaka and Peng Tan used a droplet of a colloid — a dispersion of liquid particles in another liquid, like milk — as a model for single atoms or molecules in a sphere. Unlike single atoms or molecules, which are too small to easily observe, the colloid particles were large enough to visualize using a microscope. This allowed the researchers to track the ordering of single particles in real time during crystallization.

“We visualized the organization process of colloid particles in numerous droplets under different conditions to provide a picture of the crystallization process in a sphere,” says Tan.

Based on their observations, the team proposed that the crystallization process involved three stages: initial ordering on the surface “skin” of the droplet, nucleation and growth in the core of the droplet, and then slow ripening of the whole structure. First, a skin consisting of a single layer of ordered colloid particles rapidly formed on the droplet surface. Next, crystallization occurred in the core of the droplet, far from the crystallized skin. The competition between crystallization in these two regions controlled the structure of the final crystal.

The researchers found that the “soft” (long-range) interactions between the negatively charged colloid particles affected their organization and the resulting crystal structure. These soft interactions are